Failure to detect infection by oral polio vaccine virus following natural exposure among inactivated polio vaccine recipients

Universal use of inactivated polio vaccine.

OBJECTIVES To present an update on the status of poliomyelitis worldwide, number of cases per year, regions most affected by the disease, vaccines currently available, their risks and benefits, monovalent vaccine use, risks of disseminating a mutant virus in the community, progress that has been made in terms of worldwide eradication and the World Health Organization's (WHO) proposals in this t...

Monovalent oral polio vaccine: Gates Foundation funds new polio vaccine to accelerate eradication efforts.

Immune Thrombocytopenia Following Diphtheria Pertussis- Tetanus and Oral Polio Vaccine.

intervals between affected individuals and apparently healthy subjects. Gollob, et al. [2] proposed a diagnostic criterion for SQTS. SQTS is mostly seen in males and common presentation is aborted SCD (24-32%), arrhythmias and syncope [3]. As the risk of SCD is high in SQTS, ICD placement is strongly recommended for secondary prevention. However, role of ICD in primary prevention is not well de...

Next Generation Inactivated Polio Vaccine Manufacturing to Support Post Polio-Eradication Biosafety Goals

Worldwide efforts to eradicate polio caused a tipping point in polio vaccination strategies. A switch from the oral polio vaccine, which can cause circulating and virulent vaccine derived polioviruses, to inactivated polio vaccines (IPV) is scheduled. Moreover, a manufacturing process, using attenuated virus strains instead of wild-type polioviruses, is demanded to enhance worldwide production ...

Molecular analyses of oral polio vaccine samples.

It has been suggested that the human immunodeficiency virus (HIV), and thus the acquired immunodeficiency syndrome (AIDS) it causes, was inadvertently introduced to humans by the use of an oral polio vaccine (OPV) during a vaccination campaign launched by the Wistar Institute, Philadelphia, PA, USA, in the Belgian Congo in 1958 and 1959. The "OPV/AIDS hypothesis" suggests that the OPV used in t...